The incident took place on the clockwise M25 between J10 for Guildford and J11 for Chertsey, Three lanes were shut at around 3pm, while responders attended the scene.
Motorists have been told to expect around four miles of queuing traffic and delays of half-an-hour to journey times.
National Highways tweeted: “The #M25 clockwise J10 (#A3 /#Wisley) to J11 (#Chertsey), 3 lanes (of 4) have been closed due to a collision.
“Traffic Officers are on their way to the scene. There is approx. 4 miles of congestion on approach.
“Please add an extra 30 minutes on to your current journey time.”
A car was involved in the collision at J10 near the Wisley Interchange, BBC Radio Surrey travel reports.
All traffic was temporarily held at J10 from the A3 exit.
The latest traffic cameras show congestion building back to J9 for Leatherhead.
The M25 is experiencing further delays on the clockwise stretch around west London and Hertfordshire.
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Motorists can expect 17 miles of congestion between J14 for Heathrow Airport and J19 for Watford.
The build-up is understood to be caused increased activity ahead of the Friday night rush hour.
Traffic information service Inrix said: "Queuing traffic for 17 miles on M25 clockwise from J14 A3113 Airport Way (Heathrow) to J19 (Watford).
“Travel time is 35 to 40 minutes."
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At around 4pm, National Highways confirmed the incident between J10 and J11 has been cleared to the hard shoulder.
All four lanes have now reopened, and motorists should expect to add more time to their journeys.
National Highways tweeted: “Collision has been cleared to the hard shoulder and all lanes reopened on the #M25 clockwise between J10 (#A3 / #Wisley) and J11 (#Chertsey).
“Please allow extra time for the congestion to clear.”