Station Commander Dave Bracewell, of London Fire Brigade, is at the scene in Morson Road, Enfield. He said: "Firefighters were faced with a well developed blaze on arrival.
"Crews are working hard to stop the fire spreading to surrounding buildings and a turntable ladder is in use to tackle the blaze from height.
"The fire is producing a significant amount of smoke, so residents in the area are advised to keep their doors and windows closed."
The Brigade's 999 Control Officers have taken 13 calls to the blaze, starting at 1.30am.
Firefighters from Chingford, Enfield, Edmonton, Woodford, Tottenham are attending.
The cause of the fire is not known at this stage.
UPDATE: At 4am the crew in Enfield announced that the blaze is under control, but they will remain on the scene damping down into the morning.
There are no reports of injuries at this stage.