(CNN)A new study -- the largest of its kind -- shows that hydroxychloroquine, the drug touted by President Trump, does not work against Covid-19 and could cause heart problems.
The study was published Monday in the Journal of the American Medical Association. It follows a study published Thursday in the New England Journal of Medicine that also showed the drug doesn't fight the virus.
Even before these reports were published, the US Food and Drug Administration and the National Institutes of Health issued warnings about using the drugs for coronavirus patients.
New York researcher says preliminary results of hydroxychloroquine study are ready, but state hasn't released them
In the most recent study, researchers at the University at Albany looked at 1,438 patients with coronavirus who were admitted to 25 New York City area hospitals. After statistical adjustments, the death rate for patients taking hydroxychloroquine was similar to those who did not take the drug. The death rate for those taking hydroxychloroquine plus the antibiotic azithromycin, was also similar.
However, the patients who took the drug combination were more than twice as likely to suffer cardiac arrest during the course of the study. Heart issues are a known side effect of hydroxychloroquine.
Read More
"The big takeaway for me from this study is that it's very consistent with the FDA and NIH guidelines that came out in April," said one of the study's senior authors, David Holtgrave, dean of the School of Public Health at the University at Albany. "When deciding on public health interventions and treatments for Covid-19 or any other disease, it's really important to follow the data and follow the science and make sure decisions are being made on the highest quality data possible."
Study finds no benefit, higher death rate in patients taking hydroxychloroquine for Covid-19
This study likely won't be the last word on the drugs. Researchers at the University of Washington, New York University and other centers are still testing the drug in patients.
In the clinical trials, coronavirus patients are randomly assigned to take the drugs or to take placebos, which have no effect, and then the death rates between the two groups will compared. These types of studies are considered the most reliable.
Trump's enthusiasm for hydroxychloroquine
Starting in mid-March, President Trump became a frequent cheerleader for hydroxychloroquine, used to treat malaria, lupus and other diseases and the antibiotic azithromycin, often sold under the brand name Zithromax, or as a"Z-pack."
Trump mum on hydroxychloroquine as early trials falter, but sick Americans still taking 'desperate measures' to fill prescriptions
He promoted the drugs nearly 50 times, despite pleas from scientists to let studies decide if the treatment worked or not.
"HYDROXYCHLOROQUINE & AZITHROMYCIN, taken together, have a real chance to be one of the biggest game changers in the history of medicine," Trump tweeted on March 21.
Fox News frequently echoed Trump, but both the network and the president quieted down about the drugs once studies started showing they didn't work and possibly could hurt.
No difference in death rates
Trump's enthusiasm for the drugs was based on a French study of 20 patients in March that showed the drugs might work against the virus. That study was criticized for poor methodology, with experts calling it "pathetic" and "a complete failure."
The medical society that published that study later said the study "does not meet the Society's expected standard."
But the study was enough to excite Trump, and enough to excite doctors, who were free to prescribe the drugs because they're both already on the market to treat patients with other illnesses.
The latest study in the Journal of the American Medical Association looked at the medical records of 18% of all coronavirus patients hospitalized in the New York City area from March 15 to March 28.
In this group, doctors prescribed both drugs to 735 patients, just hydroxychloroquine to 271 patients, just azithromycin to 211 patients and neither drug to 221 patients.
Get CNN Health's weekly newsletter
Sign up here to get The Results Are In with Dr. Sanjay Gupta every Tuesday from the CNN Health team.
They found that those taking hydroxychloroquine, either alone or with the antibiotic, were sicker than other patients to begin with and as time went on had a higher death rate. However, once the researchers statistically adjusted for the fact that the patients who took the drugs were sicker to start with, there was no statistical significance between the two death rates.
Overall, the patients had a 20% death rate.
The patients in the study were in the hospital, and other research teams are studying whether hydroxychloroquine can prevent coronavirus infection or slow it down in the beginning stages of the disease.
Dr. Minali Nigam, Marshall Cohen and Devon Sayers contributed to this report.
Paid Content
U.K. Prime Minister Boris Johnson Sells London Home Mansion Global
How To Get Unrestricted Internet Access Worldwide With One… ExpressVPN
Where Do The Richest Americans Live? Mansion Global
“ExpressVPN十分可靠 - 试用30天“ expressvpn
Politics Dr. Anthony Fauci is 'not surprised' some Americans are…
Health How to use Adele's birthday picture as inspiration instead of…
Health Here's what Dr. Anthony Fauci is concerned about as states reopen
Business Opinion: Billionaires are getting even richer from the pandemic…
Health States are easing coronavirus restrictions and 'it's going to cost…
Ellen DeGeneres and Portia de Rossi Flipping Montecito… Mansion Global
Mansion Global Daily: Celebs in the New York Suburbs, the Affordability Crisis and More Mansion Global
How to Protect Your Online Identity With One Simple Tool ExpressVPN
Incredible $49 Smartwatch is Taking China By Storm OshenWatch