WASHINGTON—President-elect Donald Trump picked Tesla CEO Elon Musk and biotech company founder Vivek Ramaswamy, a former Republican presidential candidate, to lead an effort to cut spending, eliminate regulations and restructure federal agencies.

       Trump said in a statement Tuesday night that Ramaswamy and Musk—the wealthiest person in the world, who oversees six companies—would lead what the president-elect called the Department of Government Efficiency, or DOGE. The group’s mandate is to streamline government bureaucracy, the president-elect said.

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