Stocks that traded heavily or had substantial price changes Friday:

       Moderna, up $2.38 to $253.98

       The vaccine maker rose as cases of the omicron variant of COVID-19 continued to spread quickly.

       Advanced Micro Devices, down $1.25 to $143.90

       The company said it was making progress on getting regulatory clearances for its acquisition of Xilinx.

       GameStop, down $6.94 to $148.39

       Shares of several “meme stocks,” which enraptured hordes of individual investors this year, fell.

       Ford, up 30 cents to $20.77

       The automaker has been one of the best-performing stocks in the S&P 500 index this year.

       Microsoft, down $3.00 to $336.32

       Technology companies lagged the rest of the market.

       Union Pacific, up $2.39 to $251.93

       Railroad operators and other industrial companies put up some of the best gains.

       PayPal, down $3.30 to $188.58

       The payments company's stock had its first annual decline since being spun off of eBay in 2015.

       Signature Bank, up $3.77 to $323.47.

       The bank is the best-performing financial stock in the S&P 500 for 2021.