Stocks that traded heavily or had substantial price changes Wednesday:

       Microsoft Corp., up $8.22 to $296.71.

       The software maker beat analysts' fiscal second-quarter profit forecasts on strong demand for its cloud-computing services and work software.

       Texas Instruments Inc., up $4.34 to $178.30.

       The chipmaker gave investors an encouraging profit forecast after reporting strong fourth-quarter financial results.

       Canadian National Railway Co., down $3.67 to $118.79.

       The railroad named a new CEO and made several changes to its board, averting a potential proxy fight with investor TCI Fund Management.

       F5 Inc., down $18.65 to $202.49.

       The computer networking company gave investors a disappointing revenue forecast as it faces supply chain constraints.

       Corning Inc., up $3.94 to $39.24.

       The specialty glass maker reported strong fourth-quarter financial results.

       Kimberly-Clark Corp., down $4.74 to $134.84.

       The maker of Kleenex tissues and other consumer goods gave investors a disappointing profit forecast for the year.

       Navient Corp., down $2.35 to $16.17.

       The student loan servicing company’s fourth-quarter profit fell short of Wall Street forecasts.

       Amphenol Corp., up 33 cents to $76.34.

       The maker of fiber-optic products reported strong fourth-quarter financial results.