The “mass casualty incident” was first picked up on emergency service scanners with fire and police services quickly arriving on scene. According to local reports between 100 to 150 workers remain trapped in the building.
First responders are working as fast as they can to rescue people from the centre.
The Edwardsville Fire Department, St. Clair County Emergency Services and multiple other fire and rescue agencies have responded to the structure collapse in Madison County.
A radio broadcast from Edwardsville Fire Department suggested portions of the roof are gone, causing between 100 and 200 yards of concrete walls to collapse into the building.
At time of writing it is not known how many people are injured, but authorities declared it a “mass casualty incident”.
The incident in Edwardsville came after a tornado warning was announced just hours prior.
According to the National Weather Service (NWS), the warning was issued across the border between Illinois and Missouri with forecasts predicting gale force winds of up to 75 mph and possible hail “the size of ping pong balls”.
National Weather Service (NWS) radar confirmed that one tornado touched down between Pontoon Beach and Edwardsville.
In neighbouring Missouri, one video shows the tornado picked up and threw multiple semi-trucks across the i-55 interstate.
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In a statement on Twitter, the Governor of Illinois Jay Robert Pritzker, offered his prayers and support to the people of Edwardsville.
He said: “My prayers are with the people of Edwardsville tonight, and I've reached out to the mayor to provide any needed state resources.
“Our @ILStatePolice and @ReadyIllinois are both coordinating closely with local officials and I will continue to monitor the situation.”
According to outage mapper Ameren, the tornado has also severely affected power to the region, with over 25,000 residents without power in Illinois and over 17,000 in Missouri.
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A video posted on Facebook by Danielle Henke, appears to show the moment the tornado struck the Amazon facility.
She captioned the video: “My brother got this video from his apartment of the tornado that hit Amazon...prayers for everyone.”
In the footage, a pillar of wind can be seen forming while pieces of debris are picked up and sent flying.
According to the NWS, portions of Bond and Fayette County remain under a tornado watch.