NEW YORK -- Stocks that traded heavily or had substantial price changes Wednesday:

       Lowe's Companies Inc., up 95 cents to $245.73.

       The home improvement retailer raised its revenue forecast for the year after reporting strong third-quarter financial results.

       Visa Inc., down $10.12 to $205.06.

       Amazon says it will stop accepting credit cards issued by the payments processor in the U.K. because of a dispute over fees.

       Target Corp., down $12.59 to $253.80.

       The retailer's profit margins were crimped by higher merchandise, freight and supply chain costs.

       TJX Companies Inc., up $4.05 to $73.55.

       The owner of T.J. Maxx, Marshalls and other retail chains reported strong third-quarter financial results.

       Varex Imaging Corp., up $3.21 to $30.05.

       The X-ray imaging technology company reported strong fourth-quarter financial results.

       Moderna Inc., up $7.95 to $242.23.

       The biotechnology company asked Canadian regulators to authorize use of its COVID-19 vaccine in children aged 6 to 11.

       Biogen Inc., down $3.17 to $258.38.

       The biotechnology company faces a possible setback in its European regulatory review for a potential Alzheimer's disease treatment.

       Valero Energy Corp., down $3.51 to $73.45.

       Crude oil and natural gas prices fell and weighed down energy companies.