Stocks that traded heavily or had substantial price changes Thursday:

       Roku Inc., down $16.84 to $403.48.

       The video streaming company fell short of Wall Street forecasts for active accounts and streaming hours during the second quarter.

       Etsy Inc., down $19.69 to $182.41.

       The online crafts marketplace gave investors a weak sales outlook for the third quarter.

       Cardinal Health Inc., down $8.41 to $50.57.

       The prescription drug distributor's fiscal fourth-quarter profit fell short of analysts' forecasts.

       Regeneron Pharmaceuticals Inc., up $21.52 to $602.47.

       The biopharmaceutical company handily beat Wall Street's second-quarter profit and revenue forecasts.

       Wynn Resorts Ltd., up $7.59 to $98.69.

       The casino operator's second-quarter loss was milder than Wall Street expected.

       Booking Holdings Inc., up $122.07 to $2,207.71

       The online travel service reported strong second-quarter bookings and revenue.

       Hanesbrands Inc., up $1.16 to $19.51.

       The underwear, T-shirt and sock maker reported strong second-quarter financial results.

       Fastly Inc., down $4.61 to $39.93.

       The cloud software developer gave investors a disappointing earnings forecast.