Vice President Kamala Harris tested positive for COVID-19 via rapid and PCR tests on Tuesday, according to her office.

       Harris, who received her second booster shot on April 1, doesn't have any symptoms.

       The vice president, 57, will isolate and work from home, Harris' press secretary, Kristen Allen, said in a statement.

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       "She has not been a close contact to the President or First Lady due to their respective recent travel schedules," the statement said. "She will follow CDC guidelines and the advice of her physicians. The Vice President will return to the White House when she tests negative."

       Harris and President Joe Biden were last seen together on April 18 at the White House Easter Egg Roll.

       Frederic J. Brown/AFP via Getty Images, FILE

       US Vice President Kamala Harris speaks during a visit to Vandenberg space force base in Lompoc, California on April 18, 2022.

       Harris traveled to California on April 18 and returned to Washington on Monday.

       Harris came to the White House Tuesday morning and tested positive during her regular testing protocol, sources told ABC News. She did not participate in any in-person meetings before testing, sources said.

       Biden and Harris spoke on the phone Tuesday afternoon to "make sure she has everything she needs as she quarantines at home," according to the White House.

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       Harris tweeted, "I will continue to isolate and follow CDC guidelines. I’m grateful to be both vaccinated and boosted."

       Harris' husband, second gentleman Doug Emhoff, tested positive for COVID-19 last month.

       Sen. Chris Murphy, D-Conn., also tested positive for COVID-19 on Tuesday.

       He said he felt "mild symptoms overnight."

       "I'm sure if I wasn't fully vaccinated I would be feeling a lot worse. So remember to get your booster!" he tweeted.

       Sen. Ron Wyden, D-Ore., also tested positive for COVID-19 on Tuesday, his office said. He is experiencing minor symptoms.

       ABC's Karen Travers reports:

       ABC News' Cecilia Vega, Sarah Kolinovsky and Molly Nagle contributed to this report.